Much to my annoyance, I siphoned a bit of flake food from last night during my weekly water change today. The Minnows hadn't eaten this large flake - in the past they have, at least some of the flakes that have gone to the gravel that is - and it'd been there all night. It does get me concerned...
I eliminated the snails I could today, it felt rather cruel but I can't take the risk in case of parasites. I also conducted a ~50% change (25 litres, but as the tank isn't quite 50 litres due to the filter, heater, airstone and plants, I'd say it may have been 52-54%). I normally do 30-40%, but this should hopefully help out on the nitrates issue to some extent, and what the male Minnow needs is a clean environment. The one female looked a little paler tonight, and it only took me 10-15 minutes to add the new water (partly temperature matched - the first 10 litres and last 5 litres were as warm if not slightly warmer than the water I removed, the middle 10 litres was cooler). I don't think they have temperature shock, though - highly active, although I could be stressing them and causing further problems doing it so fast. I don't pH match, but if they had pH shock, I'd probably know about it. I do have some Minnow fry - so I am concerned about how my approaches to changing large amounts of water affect them, as they are likely to be far more sensitive to fluctuations - but if I don't make sure the adults are well, they won't have much luck.
Somebody online suggested the possibility of Lymphocystis, of which I am aware I wouldn't really be able to do anything. Also, I've had this Minnow for 2 1/2 years at least, and for most of that time, I did have the heater on, pushing the water temperature up to 25-26C. It's now in a more suitable range of 21C-23/24C, but I have considered the possibility that the earlier stint with the higher temperatures may have accelerated the ageing of the Minnows, and if that's the case, his immune system will naturally weaken and something will probably get him eventually - regardless of how clean I keep the tank. An article I read on Columnaris pointed out that older fish can catch it in otherwise well maintained aquariums (not that this is Columnaris, but it applies to just about anything lurking in the background in any aquarium).