I gotta throw my two cents in as well.
IT's the initial start up that is the most daunting. Creating a tank that is low(er) maintenance is the goal of many people, but on the other hand there are people that don't mind a ton of maintenance, for example: instead of using skimmers and such for filtration they may do weekly or bi-weekly water changes of up to or over 30% (which can be a pretty tough maintenance schedule depending on the size and location of the tank) If you are going to set up a tank that you want to become low maintenance, the best way to do it is to be dedicated to that end from the very beginning. Every inhabitant should have it's niche, possible problems should be addressed before they happen, and a good quarantine tank should be utilized. Once you get over the initial start up period, which can take months upon months, and if you keep that end goal in mind, you will create a successful tank that doesn't just keep it's inhabitants alive, but makes it's inhabitants THRIVE.