What sort of dechlorinater did you use?
They shouldn't make any difference to medications in the water.
Most de-chlorinators are sulfur-based. SeaChem makes this warning in its Cupramine FAQ. Better safe than sorry.
What if I need to do a water change with tap water and use a dechlorinator like Prime® during the Cupramine™ treatment?
A: You will need to prepare the water 48 hours in advance of doing the water change. Add the Prime® to your buckets of replacement water 2 days prior to doing your water change. The water will immediately be dechlorinated, and 48 hours later the Prime® will no longer be active and you can perform your water change safely. Remember, that you will also have to add Cupramine™ back to the replacement water to bring it up to the final concentration of the tank. This should be done just before doing the water change.
Here is more info:
Can I use Prime with Cupramine
It's safe to use Prime® alongside any of Seachem®'s products except Cupramine™. If Prime® is added to a tank that contains Cupramine™, it converts the Cupramine™ into a more toxic form. If this happens accidentally, you'll need to remove the Cupramine™ right away using activated filter carbon or CupriSorb™. We recommend avoiding the use of Prime® during treatment with Cupramine™ entirely if possible, but if you need to do a water change, treat the new water with Prime® 48 hours before dosing the Cupramine™ so that the Prime® will be completely exhausted and there is no possibility that it will react with the Cupramine™.
Prime® will not directly interact with any of the other Seachem® products, but a large overdose of
reducing agents (conditioners like Prime®, ammonia detoxifiers, stress reducers, and some medications) can start to reduce the oxygen levels of the tank. It's just fine to use multiple reducing agents if you have good filtration and you're not using extra products unnecessarily, but if you need to use 3 or more reducing agents at the same time, it may be best to wait an hour or so between products to avoid a sudden drop in oxygen levels.