According to my bottle of myxazin, you dose every day for 5 days. If you see ammonia and/or nitrite, do a water change then add the dose. In severe cases, one course of 5 days may not be enough. In this case, I'd do a water change on day 6 then start another 5 day course.
Warning - it'll turn the water blue! Don't spill any on your clothes.
Warning - it'll turn the water blue! Don't spill any on your clothes.