The Up atomizer sounds pretty cool, but for the price I think I'll stick to my reactor diffuser as I already get 100% diffusion - can't really improve on that.
This is just a thought; do you think the Up atomizer get clogged up quite quickly? I know that the tubes from my external filter get pretty gungked up, so if the CO2 had to pass into that tube through a membrane then I think it would have trouble after a while and performance would degrade. My reactor has impellers that are constantly rotating so they never need cleaning (or haven't done in 10 months anyway).
But as you rightly say, flow is needed to diffuse CO2 in water, and I don't think you get sufficient flow from just sticking a Nano diffuser in a tank. Even if it's positioned under the outlet from the filter, there isn't enough turbulence to fully mix it - the CO2 needs to be confined so it can't escape and has not other option than to diffuse into the water - that's the only way you'll get 100% diffusion.
So, my vote is definitely for a mixer/reactor diffuser.