Mr Miagi
Veins are flowing with SW, now going back to FW!
When a sump is involved, does the tank need to be drilled?
Nope, there are overflow boxes which are made for tanks without bulkheads/drilled holes. MANY will tell you though, drill a tank before you start. Overflow boxes have been known to malfunction or be difficult at times.
Also could a tank survive (of 50 US gallons) without a sump or skimmer?
Depends what you want the set-up to contain, but sure. Many can. Both my reefs have no skimmer and no sump/fuge.