METRONIDAZOLE
Class: Antibiotic.
Indications: Anaerobic infections, malodour caused by anaerobic infection, pseudomembranous
colitis (see Clostridium difficile enteritis).
Pharmacology
Metronidazole is highly active against anaerobic bacteria and protozoa. Although it has no activity against aerobic organisms in vitro, in mixed infections in vivo both aerobes and anaerobes appear susceptible. Unlike most other antibiotics, resistance to metronidazole among anaerobes is uncommon. Metronidazole can be applied topically to malodourous fungating cancers and decubitus ulcers but is more expensive by this route.1,2 The malodour is due to volatile fatty acids produced by anaerobic bacteria. Tinidazole is similar to metronidazole with a longer duration of action; it causes less gastro-intestinal disturbance but costs more.3
Class: Antibiotic.
Indications: Anaerobic infections, malodour caused by anaerobic infection, pseudomembranous
colitis (see Clostridium difficile enteritis).
Pharmacology
Metronidazole is highly active against anaerobic bacteria and protozoa. Although it has no activity against aerobic organisms in vitro, in mixed infections in vivo both aerobes and anaerobes appear susceptible. Unlike most other antibiotics, resistance to metronidazole among anaerobes is uncommon. Metronidazole can be applied topically to malodourous fungating cancers and decubitus ulcers but is more expensive by this route.1,2 The malodour is due to volatile fatty acids produced by anaerobic bacteria. Tinidazole is similar to metronidazole with a longer duration of action; it causes less gastro-intestinal disturbance but costs more.3