I am in Byron's camp. I think the best place to put Stress guard is in the toilet.
I breed some very expensive plecos and I have shipped fish for the last 20 years. I add a small piece of PolyFilter to every bag in addition to water. My tap water is from a private well and I do not use any type of conditioner.
A formulation of patented material bonded to a synthetic matrix. By means of a special proprietary process, it is made impervious to salt while being organic-loving to certain materials. It is designed to continuously filter pollutants from the water without removing any desirable trace elements. In addition to its many features, a major benefit is its ability to maintain a nitrogen cycle balance if the biological filter malfunctions. It provides a supplemental means for the removal of ammonia when the biological filter is unable to break down excess ammonia. At that point, the "Poly Filter" absorbs the excess ammonia giving time to the biological filter to adjust to the higher ammonia input levels. All of this occurs without adding anything to the aquarium system to aid the filter and without removing any fish or invertebrates from the aquarium water.
from
https://www.poly-bio-marine.com/
Why do you think your fish need this stuff
Also, any scientist knows that the nitrifying bacteria we need in our tanks do not form spores. But SeaChem sell a product that is all spores and claims it cycles tanks. They hide in their library their old articles identifying the nitrfyers as ones that are closer to correct. the article is older and it still claims the wrong bacteria are doing the Nitrite oxidation.
SeaChem makes some good products and I use them. But they, like many other companies, produce stuff I would not use with my fish if it were free or even if they offered to pay me too use it. Most of the harm done to fish in transport relates to the aquaculture business.
Consider that in their advert they have this first sentence: "
StressGuard™ is the premium slime coat protection product. StressGuard™ will reduce stress and ammonia toxicity whenever handling or transporting fish." But the second to last sentence says,"It will not affect the pH of an aquarium, even at large doses."
There is a lot of research into transport stress. I looked and most of it relates to the aquaculture industry. I saw nothing about tank use of products used to mitigate transport stress.