The Red Mickey Mouse hid extremely well for a few hours after I did a 25% water change. She seemed to have disappeared completely until I turned the light back on to search for her. Her dorsal fin was normal and not clamped but I did see her "flash" several times and she was trailing white, thready poo, so she must have some kind of parasite. Might an improvement in water quality help her recover?
Water quality is a major factor in everything, so yes. But if there is an internal protozoan or some pathogen, treatment might be needed.