Hi, I'd never add it to the aquarium. I've used to the help in the treatment of Hexamita and other internal parasites by soaking food in epsom salt and water before feeding it to the fish. I've also used it as a bath for external cuts, sores, and parasites too - simply by adding a small amount in a jug of tank water, netting the infected fish and soaking it for a good 5 - 10 minutes and then adding the fish back to the tank and throwing the salt water away