It is one of the few Synodontis to be bred in captivity although the few successful attempts have been sketchy and they have been mostly by accident. There have been reports that they lay their eggs in a depression in the gravel and also another report when they laid them in a PVC pipe and also flowerpots. The young seemingly revert to the upside down pose when about 10 weeks old.
A good regime for a breeding setup would be to provide pipework and a few clay flowerpots with a gravel substrate and the usual plants and wood to make them feel comfortable thus giving them choices for a hopeful spawning. The females are more noticeably plumper than the males and a bit more lighter in colour.