Ah yes, the venerable eheim models. The 1048 is WAY underpowered for a sump for a display tank as large as a 4x2x2. Even the 1250 is pretty underperforming for a tank that large, but if you want to suppliment the tank's internal flowrate with powerheads then you'd be OK. Remember you're going to be dealing with 5-6 feet of head pressure MINIMUM, and the 1048 shuts off in that range. The 1250 CAN do it, but its not going to be efficient doing so. An eheim 1260 or a Mag 9.5 would probably be better choices if you want a submersible sump pump.
Remember you'll still need to suppliment the tank's internal flowrate with powerheads. Seio and Tunze are the way to go with bigger tanks