SEACHEM PRIME & SAFE;
Prime contains complexed hydrosulfite salts which removes chlorine, chloramine and ammonia. Prime also converts ammonia into a safe, non-toxic form (ammonium) that is readily removed by the tank’s nitrifying bacteria.
Prime may be used during tank cycling to alleviate ammonia/nitrite toxicity.
How Prime Converts toxic ammonia (NH3) to non toxic ammonium (NH4):
The process that takes place between Prime and toxic ammonia is not a straight conversion from NH3 to NH4.
Prime contains a binding agent that works to temporarily convert toxic ammonia (NH3) into a non toxic imidium salt using complexed hydrosulfite salts to chemically convert the ions in ammonia into a non toxic imidium salt.
It is noteworthy that this is a temporary conversion and Prime will only bind the ammonia in this form for up to 48 hours before the ions are free to re-associate into toxic NH3.
Prime also detoxifies nitrite and nitrate, allowing nitrifying and denitrifying bacteria to more efficiently remove them. It will also detoxify any heavy metals found in the tap water at typical concentration levels.
The ingredients of Prime also promote the production and regeneration of the natural slime coat and are non-acidic and will not impact pH.
While Safe is a similar dry version of Prime, with the exception that it does not detoxify heavy metals, nor will it stimulate the natural slime coat of the fish. Unfortunately, due to its dry state, those benefits can not be achieved. Safe cannot be made into Prime, as it does not have stabilizers like Prime and will not last long term in a liquid form. If diluted into a liquid, it must be used immediately.
For these reasons, for the average aquarium keeper, I generally recommend Prime over Safe.
Reference:
AAP/SeaChem Safe