I don't know what you are talking about with StressZyme and other similar products not working. They do work. Its a fact. I have read the research but thats usually done by the manufacturer so I did my own research. I added ammonia to empty tanks and used stress zyme on one and used BioSpira on one and then left one to mature naturally. While StressZyme is not as effective as BioSpira it is much better than nothing at all. Is it a cure all? No but it does work just not as well as BioSpira. I can't find any pet stores that even carry BioSpira in my area. Is fishless cycle the best way to go? Of course but most people aren't willing to let a tank sit with no fish in it for weeks. It would be best if they did but most people are very impatient.