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blister like spots on my pleco

I would watch it, partly because I have no clue what is. If it seems to be an infection, I would use a little topical betadine or iodine on it - it's an old trick from Dr Innes' aquarium bible of the pre antibiotic age. I've had it work on small fin lesions (you have to keep it out of the eyes and gills).
 

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