how many gallons are we talking about? i guess this is a new tank? with new rock? new or used bulb?
if everything (water,stats, blubs, sunlight) is in check then you have two options, goto war with it urself... or let nature goto war with it..
Ter
has your temperature been fluctuating at all? I understand that in tank of your size it is very difficult to keep the temp stable. That may be an issue as well.
If you are getting store bought RO water I would check the parameters there too. Too many time an LFS may have left their RO unit to go too long without change. Because phosphate levels should be very low with RO water. But again, give it a test and see what it gives you.
You can do a near 100% waterchange with all your livestock in the tank. I do it all the time Make sure if you have LPS to gently poke them till they close so they don't fall out of their skeletons when the water drains.