You can breed siblings several generations deep without serious problems (if the line was healthy to begin with), but after a few generations you really want to bring in new blood or at least cross lines or you will start to run into serious problems. I have found though that breeding siblings, the fry grow much slower and don't get as large usually, so for this reason I am no longer breeding siblings unless I have a REAL good reason. By breeding siblings, it allows you to really work on bringing out a trait of that line, which is why it is done so much. But there are pro's and con's to it.
Linda