You do water changes for 2 main reasons.
1) to reduce nutrients like ammonia, nitrite & nitrate.
2) to dilute disease organisms in the water.
Fish live in a soup of microscopic organisms including bacteria, fungus, viruses, protozoans, worms, flukes and various other things that make your skin crawl. Doing a big water change and gravel cleaning the substrate on a regular basis will dilute these organisms and reduce their numbers in the water, thus making it a safer and healthier environment for the fish.
If you do a 25% water change each week you leave behind 75% of the bad stuff in the water.
If you do a 50% water change each week you leave behind 50% of the bad stuff in the water.
If you do a 75% water change each week you leave behind 25% of the bad stuff in the water.
Make sure any new water is free of chlorine/ chloramine before it's added to the tank.