Once settled in Panaque spp. are very hardy, and my specimen has lived in small tanks, big tanks, buckets, brackish water, and hard water Malawi cichlid tanks! They are really only touchy for the first few weeks, maybe 3 months at the outside. During that time you need fatten them up a little. There's probably a good argument for ensuring they're the only bottom feeder in a tank during that time.
Optimal water changing in labs for maximum growth is 10-25%, 2-3 times per week.
Sexing them is not easy. Contrary to popular belief, both males AND females can develop the "whiskers", and according to at least one scientist I've spoken with, mature females with eggs have very bushy whiskers, possibly for protection. The only reliable way to sex them is by dissection. While catfish-keepers might suggest otherwise, the fish scientists working on the genus know better from collecting and dissecting these fish in the wild!
In the wild at least, Panaque are sexually mature at 20 cm, and spawning takes place during the wet season in rocky streams, usually in very specific places. The eggs are laid under rocks, out of the strong current.