No, it is not calcium. Calcium deficiency will show as blotches on the leaves that will be brown, caused by iron deposits. Cell membranes have a phospholipid bylayer that is stabilized by calcium. Iron will replace the missing calcium, so iron excess symptoms replicate the symptoms of insufficient calcium. I have very soft water and had this issue (calcium deficiency) previously.
I won't guess as to the issue here because I am not experienced with CO2 addition nor do I know the "nilo g thrive" mentioned, and your lighting obviously factors in as well. The light/nutrient availability balance can bee off due to various excesses, deficiencies, or light.